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Cl\u00faster de recerca<\/p>\n
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Persona de contacte<\/p>\n
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Eduardo Soudah<\/p>\n
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L\u00edders acad\u00e8mics<\/p>\n
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Marino Arroyo, Eduardo Soudah, Jose J. Mu\u00f1oz, Miquel Aguirre<\/p>\n
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Assessors externs<\/p>\n
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Estefan\u00eda Pe\u00f1a, Francisco Chinesta<\/p>\n
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<\/div>\n
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Aquest cl\u00faster de recerca desenvolupa m\u00e8todes computacionals per modelar estructures biol\u00f2giques, centrant-se en la mec\u00e0nica de teixits, els tractaments patol\u00f2gics, l’an\u00e0lisi de biomaterials i l’optimitzaci\u00f3 de dispositius m\u00e8dics, alhora que integra xarxes estructurals i bioqu\u00edmiques per entendre sistemes biol\u00f2gics complexos i crear solucions a trav\u00e9s de la bioenginyeria.<\/p>\n
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El cl\u00faster de recerca en Mec\u00e0nica computacional en enginyeria m\u00e8dica i mat\u00e8ria viva del CIMNE desenvolupa m\u00e8todes computacionals avan\u00e7ats per modelar, predir i analitzar el comportament mec\u00e0nic d’estructures biol\u00f2giques a m\u00faltiples escales. L’enfocament interdisciplinari del cl\u00faster combina principis d’enginyeria amb coneixements biol\u00f2gics per entendre l’evoluci\u00f3 del sistema biol\u00f2gic, simular tractaments patol\u00f2gics i optimitzar el disseny de dispositius m\u00e8dics.<\/p>\n
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El cl\u00faster se centra en quatre \u00e0rees de recerca principals: 1) modelitzaci\u00f3 biomec\u00e0nica de teixits i \u00f2rgans, 2) investigaci\u00f3 patol\u00f2gica i desenvolupament terap\u00e8utic, 3) an\u00e0lisi de biomaterials i biomaterials per a aplicacions d’enginyeria m\u00e8dica, i 4) optimitzaci\u00f3 del disseny de dispositius m\u00e8dics m\u00e9s segurs i eficients. Els investigadors creen models te\u00f2rics i computacionals sof\u00edsticats per estudiar interf\u00edcies biol\u00f2giques, com la mecanobiologia, les estructures cel\u00b7lulars i la din\u00e0mica dels teixits.<\/p>\n
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Basant-se en marcs te\u00f2rics establerts per modelar m\u00f2duls estructurals de c\u00e8l\u00b7lules i teixits, com ara els actina i citoesquelets intermedis, lesadhesions c\u00e8l\u00b7lula-c\u00e8l\u00b7lula i les matrius cel\u00b7lulars, el transport i\u00f2nic i la regulaci\u00f3 de volum. El cl\u00faster pret\u00e9n integrar aquests m\u00f2duls modelant les xarxes bioqu\u00edmiques que regulen la mecanobiologia cel\u00b7lular i tissular per poder estudiar l’organitzaci\u00f3 aut\u00f2noma i la funci\u00f3 dels sistemes biol\u00f2gics a diferents escales, amb aplicacions espec\u00edfiques en la comprensi\u00f3 dels mecanismes d’invasi\u00f3 del c\u00e0ncer.<\/p>\n
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El treball del cl\u00faster s’est\u00e9n m\u00e9s enll\u00e0 de les aplicacions sanit\u00e0ries a la biologia sint\u00e8tica, on les xarxes de senyalitzaci\u00f3 dissenyades poden dirigir l’autoorganitzaci\u00f3 de c\u00e8l\u00b7lules i teixits. A trav\u00e9s del desenvolupament continu de la seva biblioteca oberta de computaci\u00f3 d’alt rendiment \u00abhiperlife\u00bb, el cl\u00faster s’esfor\u00e7a per establir-se com a refer\u00e8ncia en mecanobiologia computacional alhora que contribueix a les innovacions en material bi\u00f2nic autoconstru\u00eft, autoreparador i multifuncional.<\/p>\n
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